TY - BOOK AU - Shargel,Leon AU - Yu,Andrew B.C. AU - Wu-Pong,Susanna TI - Applied biopharmaceutics & pharmacokinetics SN - 9780071603935 (hardcover : alk. paper) AV - RM301.4 .S52 2012 U1 - 615.7 22 PY - 2012/// CY - New York PB - McGraw-Hill KW - Biopharmaceutics KW - Pharmacokinetics KW - Models, Chemical N1 - Includes bibliographical references and index; Introduction to biopharmaceutics and pharmacokinetics -- Mathematic fundamentals in pharmacokinetics -- One-compartment open model: intravenous bolus administration -- Multicompartmental models : intravenous bolus administration -- Intravenous infusion -- Drug elimination and clearance -- Pharmacokinetics of oral absorption -- Multiple-dosage regimens -- Nonlinear pharmacokinetics -- Physiologic drug distribution and protein binding -- Drug elimination and hepatic clearance -- Pharmacogenetics -- Physiologic factors related to drug absorption -- Biopharmaceutic considerations in drug product design and in vitro drug product performance -- Drug product performance, in vivo : bioavailability and bioequivalence -- Impact of drug product quality and biopharmaceutics on clinical efficacy -- Modified-release drug products -- Targeted drug delivery systems and biotechnology products -- Relationship between pharmacokinetics and pharmacodynamics -- Application of pharmacokinetics to clinical situations -- Dosage adjustment in renal and hepatic disease; TOC; Pharmacy N2 - A textbook on the theoretical and practical applications of biopharmaceutics and pharmacokinetics. It provides you with a basic understanding of the principles of biopharmaceutics and pharmacokinetics and applies these principles to drug product development, drug product performance and drug therapy. UR - http://www.worldcat.org/title/applied-biopharmaceutics-pharmacokinetics/oclc/726074708?referer=di&ht=edition ER -