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Shargel, Leon. 1941-

Applied biopharmaceutics and pharmacokinetics / Leon Shargel, Andrew B.C. Yu. - 3rd ed. - Norwalk, Conn. : Appleton & Lange, c1993. - xxii, 625 p. : ill. ; 26 cm.

Online version:
Shargel, Leon, 1941-
Applied biopharmaceutics and pharmacokinetics.
Norwalk, Conn. : Appleton & Lange, c1993
(OCoLC)622296890

Includes bibliographical references and index.

Review of mathematical fundamentals --
Rates and orders of reactions --
Introduction to pharmacokinetics --
One-compartment open model --
Multicompartment models --
Drug distribution and protein binding --
Physiologic factors related to drug absorption --
Biopharmaceutic consideration in drug product design --
Pharmacokinetics of drug absorption --
Bioavailability and bioequivalence --
Modified-release drug products and targeted drug delivery systems --
Drug clearance --
Hepatic elimination of drugs --
Intravenous infusion --
Multiple-dosage regimens --
Nonlinear pharmacokinetics --
Application of pharmacokinetics in clinical situations --
Dosage adjustment in renal disease --
Relationship between pharmacokinetics and pharmacologic response --
Physiologic pharmacokinetic models, statistical moment, and mean residence time. TOC



ISBN: 083850129X 9780838501290

LCCN: 92022049

Subjects--Topical Terms:
Biopharmaceutics.
Pharmacokinetics.
Biopharmaceutics.
Pharmacokinetics.

LC Class. No.: RM301.4 / .S52 1993

Dewey Class. No.: 615.7 / SHA 1993

National Library of Medicine Call No.: QV38 S531a